BDBM375949 US10947243, Example 76::US9914735, Example 15::US9914735, Example 76

SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1

InChI Key InChIKey=BTWBYAOFMFQYSZ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 375949   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 169nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 1.00E+4nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 169nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 75nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK [342-635](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 2nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie Dept. of Biochemistry) in 50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 1.48E+4nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 4.62E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK [342-635](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 58.3nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 18.7nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 75nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 2nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 1.48E+4nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 4.62E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 58.3nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 1.01E+4nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM375949(US9914735, Example 15 | US9914735, Example 76 | US...)
Affinity DataIC50: 3.34E+4nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
Go to US Patent