BDBM375796 US20230382871, Compound I::US9914707, I-21

SMILES Cc1cc(NC(=O)c2cccc3cc(ccc23)-c2cccc3[nH]nc(N)c23)ccc1F

InChI Key InChIKey=SPYWRQIMSVARCX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375796   

TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM375796(US9914707, I-21 | US20230382871, Compound I)
Affinity DataIC50: 8.10nMAssay Description:The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM375796(US9914707, I-21 | US20230382871, Compound I)
Affinity DataIC50: 19.3nMAssay Description:1. ELISA Assay: The enzyme reaction substrate poly(Glu, Tyr)4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM375796(US9914707, I-21 | US20230382871, Compound I)
Affinity DataIC50: 93nMAssay Description:1. ELISA Assay: The enzyme reaction substrate poly(Glu, Tyr)4:1 was diluted to 20 μg/mL with potassium-free PBS (10 mM sodium phosphate buffer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent