BDBM375325 US10358436, Example A45::US9907800, Example A45

SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(CO)cc3)c2c1

InChI Key InChIKey=CTVWPZCQBVLKKN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 375325   

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 1.00E+3nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandPNGBDBM375325(US9907800, Example A45 | US10358436, Example A45)
Affinity DataIC50: 2.00E+3nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent