BDBM375294 US9907800, Example A19

SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cc(ccc12)C1C[C@@]11C(=O)Nc2ccc(Br)cc12

InChI Key InChIKey=SNPCIUXCKDAUAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375294   

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandPNGBDBM375294(US9907800, Example A19)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375294(US9907800, Example A19)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent