BDBM3749 N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine::Pyrimido[5,4-b]indole deriv. 40

SMILES C1CCC(CC1)Nc1ncnc2c3ccccc3[nH]c12

InChI Key InChIKey=SVDCFDHUJJDEPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 3749   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3749(N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine | Pyr...)
Affinity DataIC50: 1.00E+5nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3749(N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine | Pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR in human A-431 cell membrane vesicles using phospholipase C-gamma-1 as substrate incubated for 10 mins by scintillation counter me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed