BDBM374729 12-fluoro-5,6,7,8,14,15-hexahydro-4H-1,16- ethenopyrazolo[4,3- g][1,5,9]benzoxadiazacyclotetradecin-4-one::US10246466, Example 103::US10618912, Example 103

SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(CCc2c1)nc34

InChI Key InChIKey=MVLCLEZORCBEHN-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374729   

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  1.90nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  28nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  1.90nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  28nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent