BDBM374721 11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one::US10246466, Example 50::US10618912, Example 50

SMILES Fc1ccc2OCCNC(=O)c3cnn4ccc(NCc2c1)nc34

InChI Key InChIKey=AFTKSWNHMAKIPE-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374721   

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.570nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.570nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent