BDBM374718 14-ethyl-11-fluoro-6,7,13,14-tetrahydro-1,15- ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one::US10246466, Example 43::US10618912, Example 43

SMILES CCN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23

InChI Key InChIKey=ROQYSCDOJUQZFY-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374718   

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  3.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  3.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent