BDBM374703 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-(4-((S)-2-(methoxymethyl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride::US10246462, Example 84

SMILES COC[C@@H]1CCCN1C1CC=C(CC1C)c1cnc2c(nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1)C#N

InChI Key InChIKey=CSPFSEAYILNYDL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374703   

TargetC-C chemokine receptor type 4(Human)
Flx Bio

US Patent
LigandPNGBDBM374703(US10246462, Example 84 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 300nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent