BDBM374652 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride::US10246462, Example 33

SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CO

InChI Key InChIKey=MFJMECBECSYCCV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 374652   

TargetC-C chemokine receptor type 4(Human)
Flx Bio

US Patent
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 100nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Flx Bio

US Patent
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Flx Bio

US Patent
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 58nMAssay Description:Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374652(US10246462, Example 33 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed