BDBM374648 1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3′R,4′S)-3′-(hydroxymethyl)-[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile hydrochloride::US10246462, Example 29

SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](CO)C1)N1CCCCC1

InChI Key InChIKey=IRWBEMQQBZGECS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374648   

TargetC-C chemokine receptor type 4(Human)
Flx Bio

US Patent
LigandPNGBDBM374648(US10246462, Example 29 | 1-((R)-1-(2,4-Dichlorophe...)
Affinity DataIC50: 100nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
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Date in BDB:
1/21/2020
Entry Details
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