BDBM374184 (R)-N-((S)-1-(6-(1-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)-4-(piperidin-1-yl)-1H-indazol-6-yl)pyridin-2-yl)butyl)-2-methylpropane-2-sulfinamide::US10246456, Example 324

SMILES CCC[C@H](N[S@](=O)C(C)(C)C)c1cccc(n1)-c1cc(N2CCCCC2)c2cnn(-c3cccc(CO[Si](C)(C)C(C)(C)C)n3)c2c1

InChI Key InChIKey=RTTGFLIDGIBNRF-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374184   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Ma

US Patent
LigandPNGBDBM374184(US10246456, Example 324 | (R)-N-((S)-1-(6-(1-(6-((...)
Affinity DataIC50: 100nMAssay Description:The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Ma

US Patent
LigandPNGBDBM374184(US10246456, Example 324 | (R)-N-((S)-1-(6-(1-(6-((...)
Affinity DataEC50: <1.00E+3nMAssay Description:The cell-based assays is based on IL-6 ELISA quantification. Briefly, A549 cells are cultured in DMEM with 10% FBS medium. When cells reach 80% confl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent