BDBM373839 4-((1-benzylpiperidin-4-yl)oxy)-2,6-difluoro-3-methyl-N-(thiazol-4-yl)benzenesulfonamide formate::US10246453, Example 106::US10662184, Example 106::US11299490, Example 106

SMILES Cc1c(F)c(c(F)cc1OC1CCN(Cc2ccccc2)CC1)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=CPOQFLRCXBWCNV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 373839   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 99nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 2.06E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 2.32E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 34nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 34nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 34nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373839(US10246453, Example 106 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent