BDBM373103 1-(2-methyl-4- phenylpyrimidin-5- yl)-3-pyridin-2- ylurea::US9896447, Compound 20

SMILES Cc1ncc(NC(=O)Nc2ccccn2)c(n1)-c1ccccc1

InChI Key InChIKey=NWPAIRZLGKDVNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 373103   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373103(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-pyridin-2-...)
Affinity DataIC50: 4.00E+3nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetNT-3 growth factor receptor(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM373103(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-pyridin-2-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373103(1-(2-methyl-4- phenylpyrimidin-5- yl)-3-pyridin-2-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed