BDBM372962 US9895376, Compound 1.3

SMILES Sc1ccccc1NC(=O)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12

InChI Key InChIKey=WIZGJVWLGMIHPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372962   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Beigene

US Patent
LigandPNGBDBM372962(US9895376, Compound 1.3)
Affinity DataIC50: 88nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM372962(US9895376, Compound 1.3)
Affinity DataIC50: 5.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent