BDBM372933 ((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-fluorovinyl)-2-fluorophenyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)(morpholino)methanone::US10246429, Example 338

SMILES C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCOCC1)c1cc(\C=C(/F)c2ccc(Br)cn2)ccc1F

InChI Key InChIKey=OBVOAGZBBSFJLL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372933   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM372933(((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-...)
Affinity DataIC50: 1.10nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM372933(((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-...)
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM372933(((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-bromopyridin-2-...)
Affinity DataIC50: 3.53E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent