BDBM372718 6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropyrrolidine-1-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 122

SMILES C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCC(F)(F)C1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=FQGIAWZPFOIVNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 372718   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM372718(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropyr...)
Affinity DataIC50: 1.66nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM372718(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropyr...)
Affinity DataIC50: 69.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM372718(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(3,3-difluoropyr...)
Affinity DataIC50: 1.33E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent