BDBM372280 6-(8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimidin-4-yl)-2-oxa-6- azaspiro[3.3]heptane::US10239887, Cpd. No. 19

SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CC2(COC2)C1

InChI Key InChIKey=AHNWMSKJPGPESB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372280   

TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM372280(6-(8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimid...)
Affinity DataEC50:  456nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M4(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM372280(6-(8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimid...)
Affinity DataEC50:  1.15E+3nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent