BDBM372265 N-cyclobutyl-3,4- dimethylpyrimido[4',5':4,5] thieno[2,3-c]pyridazin-8- amine::US10239887, Cpd. No. 5

SMILES Cc1nnc2sc3c(NC4CCC4)ncnc3c2c1C

InChI Key InChIKey=SDKQUMSJHGKJIJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372265   

TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM372265(N-cyclobutyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Affinity DataEC50:  83nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M4(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM372265(N-cyclobutyl-3,4- dimethylpyrimido[4',5':4,5] thie...)
Affinity DataEC50:  112nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent