BDBM372263 3,4-dimethyl-N-(tetrahydro- 2H-pyran-4-yl) pyrimido[4',5':4,5] thieno[2,3-c]pyridazin-8- amine::US10239887, Cpd. No. 3

SMILES Cc1nnc2sc3c(NC4CCOCC4)ncnc3c2c1C

InChI Key InChIKey=SRIFPHBXTYUWFX-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372263   

TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM372263(3,4-dimethyl-N-(tetrahydro- 2H-pyran-4-yl) pyrimid...)
Affinity DataEC50:  446nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M4(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM372263(3,4-dimethyl-N-(tetrahydro- 2H-pyran-4-yl) pyrimid...)
Affinity DataEC50:  521nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent