BDBM372137 N-(2-cyanopropan-2-yl)-2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide::US10239876, Example 160::US10435407, Example 160

SMILES CC(C)(NC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O)C#N

InChI Key InChIKey=HBVBUBAJOLRKQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372137   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372137(N-(2-cyanopropan-2-yl)-2-[8-(1H-indazole-5-carbony...)
Affinity DataIC50: 33.2nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372137(N-(2-cyanopropan-2-yl)-2-[8-(1H-indazole-5-carbony...)
Affinity DataIC50: 33.2nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent