BDBM372100 N-(2-(2-((4-methylpiperazin-1-yl)methyl)phenyl)cyclopropyl)-2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)acetamide::US10239876, Example 123::US10435407, Example 123

SMILES CN1CCN(Cc2ccccc2C2CC2NC(=O)CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)CC1

InChI Key InChIKey=UVQRACPXMGFYMZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372100   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372100(N-(2-(2-((4-methylpiperazin-1-yl)methyl)phenyl)cyc...)
Affinity DataIC50: 45.6nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372100(N-(2-(2-((4-methylpiperazin-1-yl)methyl)phenyl)cyc...)
Affinity DataIC50: 45.6nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent