BDBM371865 2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl]-N-(2,2,2-trifluoroethyl)acetamide::US10239876, Example 22::US10435407, Example 22

SMILES FC(F)(F)CNC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O

InChI Key InChIKey=SYDKMYUOXNXPAU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371865   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM371865(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Affinity DataIC50: 17.3nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM371865(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Affinity DataIC50: 17.3nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM371865(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant GST-tagged human DDR1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM371865(2-[4-Oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of recombinant GST-tagged human DDR2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed