BDBM371697 N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(trifluoromethyl)phenyl)chroman-7-sulfonamide::US10239869, Example 123

SMILES Fc1cccc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2N2CCOCC2)C(F)(F)F)n1

InChI Key InChIKey=XYPYULMUTWWOKW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 371697   

LigandPNGBDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 1nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 103nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 188nMAssay Description:Inhibition of Nav1.5 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed