BDBM371635 (R)-4-(2-(1H-1,2,3-Triazol-1-yl)-4-(trifluoromethyl)phenyl)-N-(6-fluoropyridin-2-yl) chromane-7-sulfonamide::US10239869, Example 60

SMILES Fc1cccc(NS(=O)(=O)c2ccc3[C@H](CCOc3c2)c2ccc(cc2-n2ccnn2)C(F)(F)F)n1

InChI Key InChIKey=JKJIATXPNOQKCJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371635   

LigandPNGBDBM371635(US10239869, Example 60 | (R)-4-(2-(1H-1,2,3-Triazo...)
Affinity DataIC50: 0.300nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM371635(US10239869, Example 60 | (R)-4-(2-(1H-1,2,3-Triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:HEK-293 cells overexpressing the channel of interest were seeded in a 96-well plate at a density of 30000 cells/well and incubated at 37° C./5% CO2 f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM371635(US10239869, Example 60 | (R)-4-(2-(1H-1,2,3-Triazo...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed