BDBM370472 1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)ethanone;::US10233190, Example 1385

SMILES CC(=O)N1CCC(CC1)C(O)CC1c2ccccc2-c2cncn12

InChI Key InChIKey=TZLKQKCGJBWURI-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 370472   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 550nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370472(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 2.08E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed