BDBM370353 US10233189, Example 39::US10787457, Example 39::US11236096, Example 39

SMILES CCc1cc(NC(=O)c2nn(c3ncnc(N)c23)C(C)(C)C)[nH]n1

InChI Key InChIKey=OMWMITRWODCQFK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 370353   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370353(US10233189, Example 39 | US10787457, Example 39 | ...)
Affinity DataIC50: 1.53nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370353(US10233189, Example 39 | US10787457, Example 39 | ...)
Affinity DataIC50: 1.53nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370353(US10233189, Example 39 | US10787457, Example 39 | ...)
Affinity DataIC50: 1.53nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370353(US10233189, Example 39 | US10787457, Example 39 | ...)
Affinity DataIC50: 59.7nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against SRC kinase activity, the price list of LabChip-series c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
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TargetTyrosine-protein kinase Lck(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370353(US10233189, Example 39 | US10787457, Example 39 | ...)
Affinity DataIC50: 998nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against LCK kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent