BDBM370266 BDBM467161::US10233188, Example 153

SMILES CS(=O)(=O)N1CC[C@@H](Nc2ncc3cc(Cl)c(=O)n(C4CCCC4)c3n2)[C@@H](F)C1

InChI Key InChIKey=HEPANBXIOOHVED-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 370266   

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  2.20nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  2.23nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  63nMAssay Description:Inhibition of recombinant full length wild-type phosphorylated CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  63.2nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  63.2nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370266(US10233188, Example 153 | BDBM467161)
Affinity DataKi:  63.2nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent