BDBM370257 BDBM467152::US10233188, Example 144

SMILES COCCc1cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2n(C2CCCC2)c1=O

InChI Key InChIKey=IRYFCQQMVGZJKY-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 370257   

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  0.196nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  1.70nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  2.16nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  2.16nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  2.16nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  2.20nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  10.5nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  10.5nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  10.5nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370257(US10233188, Example 144 | BDBM467152)
Affinity DataKi:  163nMAssay Description:Inhibition of CDK9/Cyclin-T1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed