BDBM370192 US10233188, Example 79::US10800783, Example 79::US11396512, Example 79

SMILES C[C@]1(O)CCC[C@@H]1n1c2nc(NC3CCN(CC3)S(=O)(=O)c3nccs3)ncc2ccc1=O

InChI Key InChIKey=OFUSTOXZRPWIMF-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 370192   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  7.30nMAssay Description:Inhibition of recombinant full length wild-type phosphorylated CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  7.32nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  7.32nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  7.32nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  9.59nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  9.59nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  9.59nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM370192(US10233188, Example 79 | US10800783, Example 79 | ...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed