BDBM370130 US10233188, Example 19::US10800783, Example 19::US11396512, Example 19

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n(C3CCCCCC3)c2n1

InChI Key InChIKey=NIVRVOZNYYXNJT-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 370130   

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.350nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.350nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.350nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.960nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.960nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  0.960nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  8nMAssay Description:Inhibition of CDK9/Cyclin-T1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed