BDBM370060 (R)—N-(3-Methyl-1-(3-methyl-2,4-dioxo-1-(4-ethoxyphenyl)-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxobutan-2-yl)-3-(trifluoromethyl)-5-fluorobenzamide::US10233182, Example 244

SMILES CCOc1ccc(cc1)N1C(=O)N(C)C(=O)C11CCN(CC1)C(=O)[C@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(C)C

InChI Key InChIKey=XJJCSPWUPPUQSZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 370060   

TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM370060((R)—N-(3-Methyl-1-(3-methyl-2,4-dioxo-1-(4-et...)
Affinity DataIC50: 500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent