BDBM369957 (R)—N-(1-(1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-3-methyl-1-oxobutan-2-yl)-2-fluoro-5-(trifluoromethyl)benzamide::US10233182, Example 96

SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(Cc1ccc3OCCOc3c1)C(=O)N(C)C2=O

InChI Key InChIKey=HHMFKRVLEGYTEJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 369957   

TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM369957((R)—N-(1-(1-((2,3-Dihydrobenzo[b][1,4]dioxin-...)
Affinity DataIC50: 500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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