BDBM369944 (R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-cyclopentyl-2-oxoethyl)-2-fluoro-5-(trifluoromethyl)benzamide::US10233182, Example 57

SMILES CN1C(=O)N(c2ccc3[nH]ncc3c2)C2(CCN(CC2)C(=O)[C@H](NC(=O)c2cc(ccc2F)C(F)(F)F)C2CCCC2)C1=O

InChI Key InChIKey=NDFQOGBANFMFIE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369944   

TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM369944((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM369944((R)—N-(2-(1-(1H-Indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: 34nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed