BDBM369852 (S)-3-Methyl-N-(2-(3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)benzamide::US10233182, Example 130

SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)[C@@H](NC(=O)c2cccc(C)c2)C2CCOCC2)C1=O

InChI Key InChIKey=LEQNBKIUGXBMTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369852   

TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM369852(US10233182, Example 130 | (S)-3-Methyl-N-(2-(3-met...)
Affinity DataIC50: 1.00E+3nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM369852(US10233182, Example 130 | (S)-3-Methyl-N-(2-(3-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed