BDBM369589 US10231967, Example 97-Isomer-1

SMILES COCc1cc(cc(c1)-c1ccc2C[C@@]3(CC[C@@H](CC3)OC)[C@@]3(N=C(C)C(N)=N3)c2c1)C#N

InChI Key InChIKey=WXWZQOAPXMLOGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369589   

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM369589(US10231967, Example 97-Isomer-1)
Affinity DataIC50: 1.40nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM369589(US10231967, Example 97-Isomer-1)
Affinity DataIC50: 3.10nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent