BDBM369397 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (1,3-dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0718

SMILES CNc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc(N2CC3(CCN(C(=O)COc4cc(-c5scnc5C)ccc4CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@@H](NC(=O)C4(F)CC4)C(C)(C)C)CC3)C2)s1

InChI Key InChIKey=AVFUBHKJXBGREX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 369397   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nurix Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 369397BDBM369397(US12528814, Example 179)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details US Patent