BDBM368656 3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicyclo[3.2.1]octan-8-yl)-1-methyl-4- (trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4- methoxybenzamide.::US10227346, Example 78::US10426135, Example 78::US9920054, Example 78

SMILES COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc(C3[C@H]4CC[C@@H]3CN(C4)C(=O)C(C)C)c2c1C(F)(F)F

InChI Key InChIKey=CKMZKOSHGLFDHO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368656   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM368656(3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicycl...)
Affinity DataIC50: 2.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM368656(3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicycl...)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM368656(3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicycl...)
Affinity DataIC50: 2.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent