BDBM368615 US10227346, Example 36::US10426135, Example 36

SMILES Cc1c(NC(=O)c2cccc(c2)C#N)cnc2n(C)cc(C3CCN(CC3)C(=O)C3CC4CC[C@H]3C4)c12

InChI Key InChIKey=ZROQDFAPXXPPAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368615   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM368615(US10227346, Example 36 | US10426135, Example 36)
Affinity DataIC50: 4.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM368615(US10227346, Example 36 | US10426135, Example 36)
Affinity DataIC50: 4.5nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent