BDBM368542 1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin-3- yl)isoquinolin-6-amine::US10227343, Example 74

SMILES N(c1n[nH]c2cccnc12)c1ccc2c(nccc2c1)-n1cccn1

InChI Key InChIKey=XCIOVXDWUWYQHU-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 368542   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataEC50:  63nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataEC50:  63nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368542(1-(1H-pyrazol-1-yl)-N- (1H- pyrazolo[4,3-b]pyridin...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed