BDBM368531 N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(2- (trifluoromethyl) piperidin- 1-yl)isoquinolin-6-amine::US10227343, Example 63

SMILES FC(F)(F)C1CCCCN1c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=ZAISHRGQCCZMPK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368531   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368531(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(2- (trifluo...)
Affinity DataEC50:  306nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368531(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1-(2- (trifluo...)
Affinity DataEC50:  306nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed