BDBM368429 US10227342, Example 61

SMILES COc1cc(N(C)C[C@H]2CCCN2C)c(NC(=O)C=C)cc1Nc1ncc(C(=O)OC(C)C)c(n1)-n1ccc2ccccc12

InChI Key InChIKey=QIQBFGLTZKXCOD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368429   

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368429(US10227342, Example 61)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368429(US10227342, Example 61)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368429(US10227342, Example 61)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368429(US10227342, Example 61)
Affinity DataIC50: 300nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent