BDBM368162 3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl) sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 349

SMILES Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)[C@@H]1CN[C@H](CO)C1

InChI Key InChIKey=VYSYVEAUBVBONR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368162   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368162(3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hy...)
Affinity DataIC50: 0.220nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368162(3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hy...)
Affinity DataIC50: 0.0660nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368162(3-(2-Aminobenzo[d]thiazol-4-yl)-6-(((3 S,5S)-5-(hy...)
Affinity DataIC50: 0.452nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent