BDBM368138 3-(2-(methylsulfonamido)benzo[d]thiazol-4-yl)-6-(piperidin-4-ylsulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 325

SMILES CNc1nc2c(cccc2s1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)C1CCNCC1

InChI Key InChIKey=FFOFSTNXZUMUMU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368138   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368138(3-(2-(methylsulfonamido)benzo[d]thiazol-4-yl)-6-(p...)
Affinity DataIC50: 0.239nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368138(3-(2-(methylsulfonamido)benzo[d]thiazol-4-yl)-6-(p...)
Affinity DataIC50: 0.0720nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368138(3-(2-(methylsulfonamido)benzo[d]thiazol-4-yl)-6-(p...)
Affinity DataIC50: 0.346nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent