BDBM368054 4'- (Cyclopropanesulfonamido)- 4-(methylsulfonyl)-2-(2H- tetrazol-5-yl)-[1,1'- biphenyl]-3-sulfonamide::US10227331, Example 241

SMILES CS(=O)(=O)c1ccc(-c2ccc(NS(=O)(=O)C3CC3)cc2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=XYNDJWFFJQQRMO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368054   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368054(US10227331, Example 241 | 4'- (Cyclopropanesulfona...)
Affinity DataIC50: 0.0440nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368054(US10227331, Example 241 | 4'- (Cyclopropanesulfona...)
Affinity DataIC50: 0.658nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368054(US10227331, Example 241 | 4'- (Cyclopropanesulfona...)
Affinity DataIC50: 0.0870nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent