BDBM368000 3-(2-amino-7- methylbenzo[d]thiazol-4-yl)-6- ((R)-pyrrolidin-3-ylsulfonyl)-2- (2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 187

SMILES Cc1ccc(-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)[C@@H]2CCNC2)c2nc(N)sc12

InChI Key InChIKey=ULAJIXZNTGEIGE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368000   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368000(US10227331, Example 187 | 3-(2-amino-7- methylbenz...)
Affinity DataIC50: 0.0760nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368000(US10227331, Example 187 | 3-(2-amino-7- methylbenz...)
Affinity DataIC50: 0.0690nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368000(US10227331, Example 187 | 3-(2-amino-7- methylbenz...)
Affinity DataIC50: 0.159nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent