BDBM367977 2-((4-(4-methoxy-2- (trifluoromethyl)-1H- benzo[d]imidazol-7-yl)- 2-sulfamoyl-3-(1H- tetrazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 164

SMILES COc1ccc(-c2ccc(c(c2-c2nnn[nH]2)S(N)(=O)=O)S(=O)(=O)CCN)c2[nH]c(nc12)C(F)(F)F

InChI Key InChIKey=LLLYCIWIBFCTRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367977   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367977(US10227331, Example 164 | 2-((4-(4-methoxy-2- (tri...)
Affinity DataIC50: 0.233nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367977(US10227331, Example 164 | 2-((4-(4-methoxy-2- (tri...)
Affinity DataIC50: 0.147nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367977(US10227331, Example 164 | 2-((4-(4-methoxy-2- (tri...)
Affinity DataIC50: 0.143nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent