BDBM367902 4-(4-(2-aminoethyl sulfonyl)-3-sulfamoyl-2-(2H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboxamide::US10227331, Example 89

SMILES NCCS(=O)(=O)c1ccc(-c2cccc3sc(nc23)C(N)=O)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=KQKGDJGEBYLFRO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367902   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367902(US10227331, Example 89 | 4-(4-(2-aminoethyl sulfon...)
Affinity DataIC50: 0.601nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367902(US10227331, Example 89 | 4-(4-(2-aminoethyl sulfon...)
Affinity DataIC50: 0.277nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367902(US10227331, Example 89 | 4-(4-(2-aminoethyl sulfon...)
Affinity DataIC50: 0.152nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent