BDBM367881 4-(4-(azetidin-3-ylsulfonyl)-3-sulfamoyl-2-(1H-tetrazol-5-yl)phenyl)benzo[d]thiazole-2-carboxylic Acid::US10227331, Example 68

SMILES NS(=O)(=O)c1c(ccc(-c2cccc3sc(nc23)C(O)=O)c1-c1nnn[nH]1)S(=O)(=O)C1CNC1

InChI Key InChIKey=ZPEPUUQUXSIBTH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367881   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367881(US10227331, Example 68 | 4-(4-(azetidin-3-ylsulfon...)
Affinity DataIC50: 0.356nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367881(US10227331, Example 68 | 4-(4-(azetidin-3-ylsulfon...)
Affinity DataIC50: 0.0710nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367881(US10227331, Example 68 | 4-(4-(azetidin-3-ylsulfon...)
Affinity DataIC50: 0.256nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent