BDBM367868 3-(2-amino-1H- benzo[d]imidazol-4-yl)-6-(1- (methylsulfonyl)azetidin-3- ylsulfonyl)-2-(2H-tetrazol-5- yl)benzenesulfonamide::US10227331, Example 55

SMILES CS(=O)(=O)N1CC(C1)S(=O)(=O)c1ccc(-c2cccc3[nH]c(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=UAXLUXVRUZYHBS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367868   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367868(US10227331, Example 55 | 3-(2-amino-1H- benzo[d]im...)
Affinity DataIC50: 1.42nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367868(US10227331, Example 55 | 3-(2-amino-1H- benzo[d]im...)
Affinity DataIC50: 0.0820nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367868(US10227331, Example 55 | 3-(2-amino-1H- benzo[d]im...)
Affinity DataIC50: 0.311nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent